Burke Laboratory 

41 College St

Hanover, NH 03755

©2019 Ragusa Lab, Dartmouth College

Publications

Independent Career (Dartmouth College):

Bauer KM, Dicovitsky R, Pellegrini M, Zhaxybayeva O, Ragusa MJ. The structure of a highly conserved picocyanobacterial protein reveals a Tudor domain with an RNA binding function. Journal of Biological Chemistry 2019; 294(39):14333-14344. [Pubmed]

Gatica D, Damasio A, Pascual C, Klionsky DJ, Ragusa MJ, Popelka H. The carboxy terminus of yeast Atg13 binds phospholipid membrane via motifs that overlap with the Vac8-interacting domain. Autophagy 2019; PMID: 31352862.

Barczewski AH, Ragusa MJ, Mierke DF, Pellegrini M. The IKK-binding domain of NEMO is an irregular coiled coil with a dynamic binding interface. Scientific Reports 2019; 9(1):2950. [Pubmed]

Xia X, Katzenell S, Reinhart EF, Bauer KM, Pellegrini M, Ragusa MJ. A pseudo-receiver domain in Atg32 is required for mitophagy. Autophagy 2018; 14(9):1620-1628. [Pubmed]

Popelka H, Klionsky DJ, Ragusa MJ. An atypical BAR domain protein in autophagy. Autophagy 2018;14(7):1155-1156. [Pubmed]

Popelka H, Damasio A, Hinshaw JE, Klionsky DJ, Ragusa MJ. Structure and function of yeast Atg20, a sorting nexin that facilitates autophagy induction.Proceedings of the National Academy of Sciences 2017; 114:E10112-E21.[PubMed]

Xia X, Pellegrini M, Ragusa MJ. Backbone and side chain resonance assignments for a structured domain within Atg32. Biomolecular NMR Assignments 2017; 11: 211-4. [PubMed]

Prior to Dartmouth College:

‚ÄčKöfinger J, Ragusa MJ, Lee IH, Hummer G, Hurley JH, Solution Structure of the Atg1 Complex: Implications for the Architecture of the Phagophore Assembly Site. Structure 2015; 23: 809-818. [PubMed]

Stjepanovic G, Davies CW, Stanley, RE, Ragusa MJ, Kim DJ, Hurley JH, Assembly and dynamics of the autophagy initiating Atg1 complex. Proceedings of the National Academy of Sciences 2014; 111: 12793–12798. [PubMed]

Stanley RE, Ragusa MJ, Hurley JH. The beginning of the end: How scaffolds and coalescing vesicles nucleate autophagosome biogenesis. Trends in Cell Biology 2014; 24: 73-81. [PubMed

Jao C, Ragusa MJ, Stanley RE, Hurley JH. What the N-terminal domain of Atg13 looks like and what it does: A HORMA fold required for PtdIns 3-kinase recruitment. Autophagy 2013; 9: 1112-1114. [PubMed]

Jao C*, Ragusa MJ*, Stanley RE, Hurley JH. A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy. Proceedings of the National Academy of Sciences 2013; 110: 5486-5491. [PubMed] *These authors contributed equally to the work 

Ragusa MJ*, Stanley RE*, Hurley JH. Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis. Cell 2012; 151: 1501-1512. [PubMed] *These authors contributed equally to the work

Baskaran S, Ragusa MJ, Hurley JH. How Atg18 and the WIPIs Sense Phosphatidylinositol 3-Phosphate. Autophagy 2012; 8: 1851-1852. [PubMed]

Baskaran S, Ragusa MJ, Boura E, Hurley JH. Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy. Molecular Cell 2012; 47: 339-348. [PubMed]

Dancheck B*, Ragusa MJ*, Allaire M, Nairn AC, Page R, Peti W. Molecular Investigations of the Structure and Function of the Protein Phosphatase 1:Spinophilin:Inhibitor-2 Heterotrimeric Complex. Biochemistry 2011; 50: 1238-1246. [PubMed] *These authors contributed equally to the work

Ragusa MJ, Allaire M, Nairn AC, Page R, Peti W. Flexibility in the PP1:spinophilin holoenzyme. FEBS Letters 2011; 585: 36-40. [PubMed]

Marsh JA, Dancheck B, Ragusa MJ, Allaire M, Forman-Kay JD, Peti W. Structural diversity in free and bound states of intrinsically disordered protein Phosphatase 1 regulators. Structure 2010; 18: 1094-1103. [PubMed]

Bollen M, Peti W, Ragusa MJ, Beullens M. The Extended PP1 toolkit: designed to create specificity. Trends in Biochemical Sciences. 2010; 35: 450-458. [PubMed]   

Ragusa MJ, Dancheck B, Critton DA, Nairn AC, Page R, Peti W. Spinophilin directs protein phosphatase 1 specificity by blocking substrates binding sites. Nature Structural and Molecular Biology 2010; 17: 459-464. [PubMed]

Sterne-Marr R, Leahey PA, Bresee JE, Dickson HM, Ho W, Ragusa MJ, Donnelly RM, Arnie SM, Krywy JA, Brookins-Danz ED, Orakwue SC, Carr MJ, Yoshino-Koh K, Li Q, Tesmer JJ. GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail. Biochemistry 2009; 48: 4285–4293. [PubMed]

Li H, Radford JC, Ragusa MJ, Shea KL, Mckercher SR, Zaremba, Soussou W, Nie Z, Kang YJ, Nakanishi N, Okamoto S, Roberts AJ, Schwarz JJ, Lipton SA, Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proceedings of the National Academy of Sciences 2008; 105: 9397–9402. [PubMed]

Ju T, Ragusa MJ, Hudak J, Nairn AC, Peti W. Structural characterization of the neurabin sterile alpha motif domain. Proteins 2007; 69: 192–198. [PubMed]

Vong LH, Ragusa MJ, Schwarz JJ. Generation of conditional Mef2cloxp/loxp mice temporal- and tissue-specific analysis. Genesis 2005; 43: 43-48. [PubMed]