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Recent Publications
2025
Reconstitution of autophagic-like membrane tethering reveals that Atg11 can bind and cluster vesicles on cargo mimetics
Autophagy 2025
DOI: 10.1080/15548627.2025.2551678
2023
A Comparative Analysis of the Membrane Binding and Remodeling Properties of Two Related Sorting Nexin Complexes
Involved in Autophagy
Biochemistry 2023
2022
Characterization of Protein-Membrane Interactions in Yeast Autophagy
Kelsie A Leary, Michael J Ragusa
Cells 2022
​​​Keywords: autophagy; membrane binding proteins; yeast.
Dimerization-dependent membrane tethering by Atg23 is essential for yeast autophagy
Wayne D Hawkins, Kelsie A Leary, Devika Andhare, Hana Popelka, Daniel J Klionsky, Michael J Ragusa
​Keywords: CP: Cell biology; autophagy; lysosome; membrane tether; stress; vacuole.
Cell Reports 2022
DOI: 10.1016/j.celrep.2022.110702
2021
Membrane Binding and Homodimerization of Atg16 Via Two Distinct Protein Regions is Essential for Autophagy in Yeast
Hana Popelka, Erin F Reinhart, Shree Padma Metur, Kelsie A Leary, Michael J Ragusa, Daniel J Klionsky
Journal of Molecular Biology 2021
2020
A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance
Erin F Reinhart, Nicole A Litt, Sarah Katzenell, Maria Pellegrini, Ai Yamamoto, Michael J Ragusa
Traffic 2020
DOI: 10.1111/tra.12771
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Keywords: ALFY; FYVE domain; autophagy; nuclear magnetic resonance spectroscopy; phosphatidylinositol 3-phosphate; protein structure.
The Third Coiled Coil Domain of Atg11 Is Required for Shaping Mitophagy Initiation Sites
Hannah K Margolis, Sarah Katzenell, Kelsie A Leary, Michael J Ragusa
Journal of Molecular Biology 2020
DOI: 10.1016/j.jmb.2020.08.025
Keywords: Atg11; autophagy; crystal structure; mitophagy.
More Publications
2020-2017
Production, Crystallization, and Structure Determination of the IKK-binding Domain of NEMO
A pseudo-receiver domain in Atg32 is required for mitophagy
Structure and function of yeast Atg20, a sorting nexin that facilitates autophagy induction
Xue Xia, Maria Pellegrini, Michael J Ragusa
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