Ragusa Lab | Dartmouth College

We are exploring the molecular mechanisms of selective autophagy, a catabolic cellular process which targets specific cytosolic material for degradation in the lysosome. We use a diverse set of techniques including X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, biochemistry and cell biology.

We are actively accepting in person and virtual rotation students for 2020-2021 to join our team.

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Latest News

Ragusa Lab

Structure of Atg11 CC3

Check out our latest paper revealing the first structure for any region of Atg11 and its role in shaping mitophagy initiation sites. http...

Ragusa Lab

August 17, 2020

Congratulations to Dr. Xue Xia (Sherry) on her thesis defense! Great job, Dr. Xia!

Ragusa Lab

May 29, 2020

Congrats to Hannah Margolis for defending her Senior Honors Thesis in the Chemistry Department. Best of luck as a Post-Baccalaureate Rese...

SELECTED PUBLICATIONS

The structure of a highly-conserved picocyanobacterial protein reveals a Tudor domain with an RNA-binding function.

Bauer KM, Dicovitsky R, Pellegrini M, Zhaxybayeva O, Ragusa MJ.

J Biol Chem. 2019 Sep 27;294(39):14333-14344.

PMID: 31391250

A pseudo-receiver domain in Atg32 is required for mitophagy.

Xia X, Katzenell S, Reinhart EF, Bauer KM, Pellegrini M, Ragusa MJ.

Autophagy. 2018;14(9):1620-1628.

PMID: 29909755

The carboxy terminus of yeast Atg13 binds phospholipid membrane via motifs that overlap with the Vac8-interacting domain.

Gatica D, Damasio A, Pascual C, Klionsky DJ, Ragusa MJ, Popelka H.

Autophagy. 2019 Aug 2:1-14.

PMID: 31352862

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Learn more about the research conducted in the Ragusa Lab.